Dr. Jim Stoppani puts on a Master Class on how to maximize muscle pumps

By Joe Wuebben

“The pump was insane...which made me want to work out even longer and harder.*”

That’s the kind of pump everyone wants during their workout (and even in the hours after the workout is over), and the only way to get that is with the right pre-workout.*

While many products fall short when trying to deliver result-producing, long-lasting pumps each and every training session––this can be achieved by understanding how the body actually works.*

Someone like Pre JYM X co-founder and formulator Dr. Jim Stoppani.

The first step in formulating a supplement for a killer pump is to look at all the pathways in the body that cause blood vessels to relax (called vasodilation) so that blood can flow freely and engorge the muscles being trained. That’s because there’s more than one pathway in the body that is involved in delivering a pump, but many popular pre-workouts still only access one.

Setting the stage for a maximum pump

When formulating for the pump, the most critical pathway is the L-Arginine-Nitric Oxide Pathway. That’s why having high arginine levels in the body increases Nitric Oxide (NO) which helps blood vessels relax, something that’s essential for a great pump. The problem is, while arginine is the biological precursor of NO, we now know that supplementing with citrulline malate increases arginine levels far better than taking arginine itself, making it the best ingredient for that function.*

Dr. Stoppani pioneered using citrulline malate for greater pumps nearly 10-years ago, which is why Pre JYM X delivers 8 grams of citrulline malate, providing the base on which to build an amazing pump effect .*

Greater Pumps with Nitrates

Once arginine levels are increased with citrulline malate, we can use the Nitrate–Nitrite–Nitric Oxide Pathway to move towards maximum muscle hyperemia – which is a fancy term that means there is a greater amount of blood collecting in the working muscles. Pre JYM X effectively pushes this pathway directly with nitrates, specifically 2 grams of citrulline nitrate and 1 gram of betaine nitrate per serving, providing an industry-leading 860 milligrams of nitrates.* Not only that, these nitrates are bound to amino acids to help enhance absorption.*

Finally, by stimulating the pathway known as Nitric Oxide Synthase (eNOS), which is the body's enzyme that produces nitric oxide naturally, we can support even greater nitric oxide production.* Pre JYM X contains 180 milligrams of Pine Bark Extract per serving, which raises eNOS, and because it is also an antioxidant it can help neutralize free radicals caused by exercise, which can ensure NO molecules remain stable, prolonging their availability in the body.*

As you can see, once you know the science, it all makes sense. Of course, Dr. Jim Stoppani knows the science and how to apply it for the best possible results as well as anyone else. That’s why Pre JYM X takes muscle pumps to another level with a multi-ingredient strategy that augments muscle pumps, fullness, and vasodilation.*


In the above video, Dr. Stoppani breaks down the pathways behind the pump and explains what ingredients need to be in your pre-workout to experience the best pumps possible. *

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


1Agarwal, Umang et al. “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.” The Journal of nutrition vol. 147,4 (2017): 596-602. doi:10.3945/jn.116.240382

2Wax, Benjamin1; Kavazis, Andreas N.2; Weldon, Kevin1; Sperlak, Joseph1 Effects of Supplemental Citrulline Malate Ingestion During Repeated Bouts of Lower-Body Exercise in Advanced Weightlifters, Journal of Strength and Conditioning Research: March 2015 - Volume 29 - Issue 3 - p 786-792. doi: 10.1519/JSC.0000000000000670

3Weitzberg E, Hezel M, Lundberg JO. Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology. 2010 Dec;113(6):1460-75. doi: 10.1097/ALN.0b013e3181fcf3cc. PMID: 21045638.

4Mamoru Ohkita, Yoshinobu Kiso, Yasuo Matsumura, Pharmacology in Health Foods: Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol),Journal of Pharmacological Sciences, Volume 115, Issue 4, 2011, Pages 461-465,

Tags: Pre Workout